Journal of Exotic Pet Medicine
Volume 19, Issue 1 , Pages 101-104 , January 2010

Sucralfate

  • Becky Dallwig, DVM

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Becky Dallwig, DVM, University of Illinois, College of Veterinary Medicine, Urbana, IL 61802

References 

  1. Plumb DC. Sucralfate. In:  Plumb DC editors. Plumb's Veterinary Drug Handbook. (ed 6). Ames, IA: Blackwell Publishing; 2008;p. 1130–1131
  2. Yokel RA, Dickey KM. Mucosal injury and gamma-irradiation produce persistent gastric ulcers in the rabbit (Evaluation of antiulcer drug binding to experimental ulcer sites). Gastroenterology. 1991;100(5):1201–1205
  3. Garcia-Paredes J, Rubio D, Llenas F, et al. Comparison of sucralfate and ranitidine in the treatment of duodenal ulcers. Am J Med. 1991;91(2A):64–67
  4. Rees WD. Mechanisms of gastroduodenal protection by sucralfate. Am J Med. 1991;91(2A):58–63
  5. Singh K, Nain CK, Singh V, et al. Effect of sucralfate on gastric bicarbonate secretion in patients with duodenal ulcer. Indian J Gastroenterol. 1995;14(2):48–50
  6. Shorrock CJ, Garner A, Hunter AH, et al. Effect of bismuth subcitrate and sucralfate on rat duodenal and human gastric bicarbonate secretion in vivo. Gut. 1990;31:26–31
  7. Crampton JR, Gibbons LC, Rees W. Effects of sucralfate on gastroduodenal bicarbonate secretion and prostaglandin E2 metabolism. Am J Med. 1987;83(3B):14–18
  8. Hollander D, Tarnawski A, Gergely H, et al. Sucralfate protection of the gastric mucosa against ethanol-induced injury: a prostaglandin-mediated process?. Scand J Gastroenterol. 1984;101(Suppl):97–102
  9. Mall A, Fourie J, McLeod H, et al. Administration of sucralfate prolongs survival of animals with experimental peptic ulceration. Am J Med. 1991;91(2A):37–42
  10. Marks IN, Johnston DA, Young GO. Acid secretory changes and early relapse following duodenal ulcer healing with ranitidine and sucralfate. Am J Med. 1991;91(2A):95–101
  11. Fabian TC, Boucher BA, Croce MA, et al. Pneumonia and stress ulceration in severely injured patients (A prospective evaluation of effects of stress ulcer prophylaxis). Arch Surg. 1993;128(2):185–191
  12. Kuwayama H, Matsuo Y, Eastwood GL. Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat. Am J Med. 1991;91(2A):15–19
  13. Maier RV, Mitchell D, Gentilello L. Optimal therapy for stress gastritis. Ann Surg. 1994;220(3):353–360
  14. Clark S, Katz PO, Wu WC, et al. Comparison of potential cytoprotective action of sucralfate and cimetidine. Am J Med. 1987;83(3B):28–60
  15. Schweitzer EJ, Bass BL, Johnson LF, et al. Sucralfate prevents experimental peptic esophagitis in rabbits. Gastroenterol. 1985;88(3):611–619
  16. Caldwell JR, Roth SH, Wu W, et al. Sucralfate treatment of nonsteroidal anti-inflammatory drug-induced gastrointestinal symptoms and mucosal damage. Am J Med. 1987;83(3B):74–94
  17. Maton PN. Profile and assessment of GERD pharmacology. Cleve Clin J Med. 2003;70(5):51–70
  18. Richter JE. Gastroesophageal reflux disease during pregnancy. Gastroenterol Clin North Am. 2003;32(1):235–261
  19. Simjee AE, Pettengell KE, Spitaels JM. Comparative study of sucralfate 2 grams twice daily versus sucralfate 1 gram four times daily in the treatment of benign gastric ulcers in outpatients. Am J Med. 1991;91(2A):68–70
  20. Fisher RS. Sucralfate: a review of drug tolerance and safety. J Clin Gastroenterol. 1981;3(2):181–184
  21. Odeh M, Oliven A. Hepatotoxicity related to sucralfate. Hepatol Res. 2001;20(2):255–258
  22. Allain P, Mauras Y, Krari N, et al. Plasma and urine aluminum concentrations in healthy subjects after administration of sucralfate. Br J Clin Pharmacol. 1990;29:391–395
  23. Mistry P, Varghese Z, Pounder RE. Short report: plasma aluminum concentration and 24-hour urinary aluminum excretion before, during and after treatment with sucralfate. Aliment Pharmacol Ther. 1991;5(5):549–553
  24. Burgess E, Muruve D, Audette R. Aluminum absorption and excretion following sucralfate therapy in chronic renal insufficiency. Am J Med. 1992;92:471–475
  25. Hemstreet BA. Use of sucralfate in renal failure. Ann Pharmacother. 2001;35(3):360–364
  26. Abd-Elghaffar S, El-Sokkary GH, Sharkawy AA. Aluminum-induced neurotoxicity and oxidative damage in rabbits: protective effect of melatonin. Neuro Endocrinol Lett. 2005;26(5):609–616
  27. Bharathi , Vasudevaraju P, Govindaraju M, et al. Molecular toxicity of aluminum in relation to neurodegeneration. Indian J Med Res. 2008;128(4):545–556
  28. Ribes D, Colomina MT, Vicens P, et al. Effects of oral aluminum exposure on behavior and neurogenesis in a transgenic mouse model of Alzheimer's disease. Exp Neurol. 2008;214(2):293–300
  29. Rodella LF, Ricci F, Borsani E, et al. Aluminum exposure induces Alzheimer's disease-like histopathological alterations in mouse brain. Histol Histopathol. 2008;23(4):433–439
  30. Kawahara M. Effects of aluminum on the nervous system and its possible link with neurodegenerative disease. J Alzheimers Dis. 2005;8:171–182
  31. Schöll I, Untersmayr E, Bakos N, et al. Antiulcer drugs promote oral sensitization and hypersensitivity to hazelnut allergens in BALB/c mice and humans. Am J Clin Nutr. 2005;81(1):154–160
  32. Pali- Schöll I, Yildirim Aö, Ackermann U, et al. Anti-acids lead to immunological and morphological changes in the intestine of BALB/c mice similar to human food allergy. Exp Toxicol Path. 2008;60:337–345
  33. Brunner R, Wallmann J, Szalai K, et al. Aluminum per se and in the anti-acid drug sucralfate promotes sensitization via the oral route. Allergy. 2009;64(6):890–897
  34. Smart HL, Somerville KW, Williams J, et al. The effects of sucralfate upon phenytoin absorption in man. Br J Clin Pharmacol. 1985;20(3):238–240
  35. Rey AM, Gums JG. Altered absorption of digoxin, sustained release quinidine, and warfarin with sucralfate administration. DICP. 1991;25:745–746
  36. Nix DE, Watson WA, Handy L, et al. The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin. Pharmacotherapy. 1989;9(6):377–380
  37. Van Slooten AD, Nix DE, Wilton JH, et al. Combined use of ciprofloxacin and sucralfate. DICP. 1991;25(6):578–582
  38. Hulisz D, Miller K. Update on quinolone drug interactions. Am Pharm. 1990;30(9):34–36
  39. Lehto P, Kivistö KT. Effect of sucralfate on absorption of norfloxacin and ofloxacin. Antimicrob Agents Chemother. 1994;38(2):248–251
  40. Orlando RC, Turjman NA, Tobey NA. Mucosal protection by sucralfate and its components in acid-exposed rabbit esophagus. Gastroenterol. 1987;93(2):352–361
  41. Carpenter JW. Exotic Animal Formulary. (ed. 3). St. Louis, MO: Elsevier Inc; 2005;
  42. Katz PO, Geisinger KR, Hassan M, et al. Acid-induced esophagitis in cats is prevented by sucralfate but not synthetic prostaglandin E. Dig Dis Sci. 1988;33(2):217–224
  43. Mazzei MJ, Bissett S, Murphy M, et al. Eosinophilic esophagitis in a dog. J Am Vet Med Assoc. 2009;235(1):61–65
  44. Hoshino T, Takano T, Tomisato W, et al. Effects of sucralfate on gastric irritant-induced necrosis and apoptosis in cultured guinea pig gastric mucosal cells. Biol Pharm Bull. 2003;26(1):24–27
  45. Hanson SM, Bostwick DR, Twedt DC, et al. Clinical evaluation of cimetidine, sucralfate, and misoprostol for prevention of gastrointestinal tract bleeding in dogs undergoing spinal surgery. Am J Vet Res. 1997;58(11):1320–1323
  46. George RJ, Petri L, Papich MG, et al. The protective effects of sucralfate and ranitidine in foals experimentally intoxicated with phenylbutazone. Can J Vet Res. 1989;53(2):231–238
  47. Sykes JM, Greer L, Allen JL, et al. Oral eosinophilic granulomas in tigers (Panthera tigris): a collection of four cases. Proc Am Assoc Zoo Vet. 2004;118:45
  48. Gladden JN. Clinical management of potential ibuprofen toxicosis in a South American red-footed tortoise (Geochelone carbonaria). Vet Clin Exotic Anim. 2006;9:599–607
  49. Ritchie BW, Harrison GJ. Formulary. In:  Ritchie BW,  Harrison GJ,  Harrison LR editor. Avian Medicine: Principles and Applications. Lake Worth, FL: Wingers Publishing; 1994;p. 457–478

PII: S1557-5063(10)00012-1

doi: 10.1053/j.jepm.2010.01.011

Journal of Exotic Pet Medicine
Volume 19, Issue 1 , Pages 101-104 , January 2010