Journal of Exotic Pet Medicine
Volume 17, Issue 4 , Pages 307-310 , October 2008

Fenbendazole

  • Brittany Heggem, BS

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Brittany Heggem, BS, University of Illinois, College of Veterinary Medicine, 1008 W. Hazelwood Drive, Urbana, IL 61802

References 

  1. Lacey E, Gill JH. Biochemistry of benzimidazole resistance. Acta Trop. 1994;56:245–262
  2. Marriner S, Bogan JA. Pharmacokinetics of oxfendazole in sheep. Am J Vet Res. 1981;42:1143–1145
  3. McCracken RO, Lipkowitz KB. Structure-activity relationships of benzothiazole and benzimidazole anthelmintics: a molecular modeling approach to in vivo drug efficacy. J Parasitol. 1983;76:853–864
  4. Bogan J, Armour J. Anthelmintics for ruminants. Int J Parasitol. 1987;17:483–491
  5. Bogan JA, Marriner SE. Pharmacokinetics of fenbendazole, albendazole and oxfendazole. In:  Ruckelbusch Y,  Toutain PL,  Karitz GD editor. Veterinary Pharmacology and Toxicology. Lancaster, England: MTP Press; 1983;p. 235–240
  6. Short CR, Barker SA, Hsie LC, et al. Disposition of fenbendazole in the goat. Am J Vet Res. 1987;48:81–815
  7. Weber MA, Miller MA, Neiffer DL, et al. Presumptive fenbendazole toxicosis in North American porcupines. J Am Vet Med Assoc. 2006;299:1240–1242
  8. Plumb DC. Fenbendazole. In:  Plumb DC editors. Veterinary Drug Handbook. (ed 4). Ames, IA: Blackwell Publishing; 2002;p. 340–343
  9. Duwel D. Fenbendazole II biological properties and activity. Pesticide Sci. 1977;8:550–555
  10. Bonar CJ, Lewandowski AH, Schaul J. Suspected fenbendazole toxicosis in 2 vulture species (Gyps africanus, Torgos tracheliotus) and Marabou storks (Leptoptilos crumeniferus). J Avian Med. 2003;17:16–19
  11. Short CR, Flory W, Hsieh LC, et al. The oxidative metabolism of fenbendazole: a comparative study. J Vet Pharmacol Ther. 1988;11:50–55
  12. Averkin EZ, Beard CC, Dvorak CA, et al. Methyl 5(6)-phenylsufinyl-2-benzimidazolecarbamate, a new, potent anthelmintic. J Med Chem. 1975;18:1164–1166
  13. Friedman PA, Platzer EG. Interaction of anthelmintic benzimidazoles with Ascaris suum embryonic tubulin. Biochim Biophys Acta. 1980;630:271–278
  14. Gozalo AS, Schwiebert RS, Lawson GW. Mortality associated with fenbendazole administration in pigeons (Coumba livia). J Am Assoc Lab Anim Sci. 2006;45:63–66
  15. Sangster NC, Prichard RK, Lacey E. Tubulin and benzimidazole-resistance in Trichostrongylus colubriformis (nematode). J Parasitol. 1985;71:645–651
  16. Lacey E, Gill JH. Biochemistry of benzimidazole resistance. Acta Trop. 1994;56:245–262
  17. Barrowman MM, Marriner SE, Bogan JA. The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics. Biochem Pharmacol. 1984;33:3037–3040
  18. Kohler P, Bachman R. Intestinal tubulin as possible target for the chemotherapeutic action of menbendazole in parasitic nematodes. Molec Biochem Parasitol. 1981;4:425-226
  19. Campbell WC. Benzimidazoles: veterinary uses. Parasitol Today. 1990;6:130–133
  20. Holt PE, Lawrence K. Efficacy of fenbendazole against the nematodes of reptiles. Vet Rec. 1982;110:302–304
  21. Ramisz A, Skotnicki J, Krazkowski A. Efficacy of fenbendazole (Panacur) against trichuriasis and ancylostomiasis in monkeys. Medycyna Weterynaryjna. 1978;34:523–524
  22. McKeller WA, Gokbulut C, Muzandu K, et al. Fenbendazole pharmacokinetics, metabolism, and potentiation in horses. Drug Metab Dispos. 2002;30:123–129
  23. Prichard RK, Hennessy DR, Steel JW. Prolonged administration: a new concept for increasing the spectrum and effectiveness of anthelminthics. Vet Parasitol. 1978;4:309–315
  24. Mikolon AB, Boyce WM, Allen JL, et al. Epidemiology and control of nematodes in captive exotic ungulates. J Zoo Wildl Med. 1994;24:500–510
  25. Jones LC, Worley DE. Use of fenbendazole for long-term control of protostrongylid lungworms in free-ranging Rocky Mountain bighorn sheep. J Wildl Med. 1997;33:364–367
  26. Connan RM. Hypobiosis in the ostertagiids of red deer and the efficacy of ivermectin and fenbendazole against them. Vet Rec. 1997;140:203–205
  27. Kock RA. Enteric nematode infestation in Thomson's gazelles, Gazella thomsoni, at Whipsnade Park, the Zoological Society of London. J Zoo Anim Med. 1986;17:61–64
  28. Melbourne CP. Observations on treatment of endoparasites in giraffes. J Zoo Anim Med. 1978;9:146–148
  29. Goldstein EJ, Millspaugh JJ, Washburn BE, et al. Relationships among fecal lungworm loads, fecal glucocorticoid metabolites and lamb recruitment in free-ranging Rocky Mountain bighorn sheep. J Wildl Dis. 2005;41:416–425
  30. Baker DG, Cook LF, Johnson EM, et al. Prevalence, acquisition and treatment of nematode infection in opposums. J Zoo Wildl Med. 1995;26:403–408
  31. Brannian RE. Treatment for bronchial capillariasis in Arctic foxes with fenbendazole. J Zoo Anim Med. 1985;16:66–68
  32. Loomis MR, Wright JF. Gastric trichuriasis in a black and white colobus monkey. J Am Vet Med Assoc. 1986;189:1214–1215
  33. Hasegawa H, Udono T. Chimpanzee pinworm, Enterobius anthropopitheci (nematode: Oxyuridae), maintained for more than twenty years in captive chimpanzees in Japan. J Parasitol. 2007;93:850–855
  34. Lee GY, Boyce WM, Orr K. Diagnosis and treatment of lungworm infection in white-faced capuchins. J Zoo Wildl Med. 1996;27:197–200
  35. Forstner MJ, Regensburger J, Claussen J. Studies on the medicinal control of helminthes in tortoises. Vet Med Rev. 1983;1:10–15
  36. Giannetto S, Brianti E, Poglayen G, et al. Efficacy of oxfendazole and fenbendazole against tortoise (Testudo hermanni) oxyurids. Parasitol Res. 2007;100:1069–1073
  37. Rideout BA, Montali RJ, Phillips LG, et al. Mortality of captive tortoises due to viviparous nematodes of the genus Proatractis (family Atractidae). J Wildl Dis. 1987;23:103–108
  38. Holt PE, Lawrence K. Efficacy of fenbendazole against the nematodes of reptiles. Vet Rec. 1982;110:302–304
  39. Stehle S. The treatment of helminthiasis in birds of prey with fenbendazole. Kleintier Praxis. 1977;22:261–266
  40. Villanua D, Acevedo P, Hofle U, et al. Changes in parasite transmission stage excretion after pheasant release. J Helminth. 2006;80:313–318
  41. McOrist S, Barton NJ, Black DG. Acuaris skrjabini infection of the gizzard of finches. Avian Dis. 1982;26:957–960
  42. Grimes J, Suto B, Greve JH, et al. Effect of selected anthelmintics on three common helminthes in the brown pelican (Pelecanus occidentalis). J Wildl Dis. 1989;25:139–142
  43. Lawrence K. Efficacy of fenbendazole against nematodes of captive birds. Vet Rec. 1983;112:433–434
  44. Devriese LA. Fenbendazole treatment of nematodes in birds. Vet Rec. 1983;112:509
  45. Weber MA, Terrell SP, Neiffer DL, et al. Bone marrow hypoplasia and intestinal crypt cell necrosis associated with fenbendazole administration in five painted storks. J Am Vet Med Assoc. 2002;221:417–419

PII: S1557-5063(08)00128-6

doi: 10.1053/j.jepm.2008.07.009

Journal of Exotic Pet Medicine
Volume 17, Issue 4 , Pages 307-310 , October 2008

Article Tools