Journal of Exotic Pet Medicine
Volume 16, Issue 3 , Pages 158-167 , July 2007

Common Ophthalmic Problems in Pet Rabbits

  • Frank Wagner, Dr med vet

      Affiliations

    • Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    • Corresponding Author InformationAddress correspondence to: Frank Wagner, Dr. med. vet., Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.154, 3508 TD Utrecht, The Netherlands.
  • ,
  • Michael Fehr, Prof Dr med vet

      Affiliations

    • Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.

References 

  1. Abrams KL, Brooks DE, Funk RS. Evaluation of Schirmer tear test in clinically normal rabbits. Am J Vet Res. 1990;51:1912–1913
  2. Biricik HS, Oguz H, Sindak N, et al. Evaluation of the Schirmer and phenol red thread tests for measuring tear secretion in rabbits. Vet Rec. 2005;156:485–487
  3. Williams DL. Laboratory animal ophthalmology. In:  Gelatt KN editors. Veterinary Ophthalmology. (ed 3). Baltimore: Lippincott Williams & Wilkins; 1999;p. 1209–1236
  4. Harcourt-Brown F. Calcium deficiency, diet and dental disease in pet rabbits. Vet Rec. 1996;139:567–571
  5. Burling K, Murphy CJ, Curiel JS. Anatomy of the rabbit nasolacrimal duct and its clinical implications. Prog Vet Comp Ophthalmol. 1991;1:33–40
  6. Marini RP, Foltz CJ, Kersten D, et al. Microbiologic, radiographic and anatomic study of the nasolacrimal duct apparatus in the rabbit (Oryctolagus cuniculus). Lab Anim Sci. 1996;46:656–662
  7. Yanoff SR. Surgical correction for entropium in a baby rabbit. Vet Med Small Anim Clin. 1983;78:1882–1883
  8. Fox JG, Shalev M, Beaucage CM, et al. Congenital entropium in a litter of rabbits. Lab Anim Sci. 1979;29:509–511
  9. Wagner F, Heider HJ, Görig C, et al. Augenkrankheiten beim Zwergkaninchen. Teil 1: Anatomie, Untersuchungsgang, Erkrankungen der Augenlider, der Konjunktiva und des Tränennasengangs. Tierärztl Prax. 1998;26:205–210
  10. Kern TJ. Rabbit and rodent ophthalmology. Semin Avian Exotic Pet Med. 1997;6:138–145
  11. Snyder SB, Fox JG, Campell LH, et al. Disseminated staphylococcal disease in laboratory rabbits (Oryctolagus cuniculus). Lab Anim Sci. 1976;26:86–88
  12. Srivastava KK, Pick JR, Johnson PT. Characterization of a Hemophilus sp. isolated from a rabbit with conjunctivitis. Lab Anim Sci. 1986;36:291–293
  13. Patton NM, Holmes HT. Myxomatosis in domestic rabbits in Oregon. J Am Vet Med Assoc. 1977;171:560–562
  14. Harkness JE, Wagner JE. The Biology and Medicine of Rabbits and Rodents. (ed 3). Philadelphia: Lea & Febiger; 1989;
  15. Hinton M. Treatment of purulent staphylococcal conjunctivitis in rabbits with autogenous vaccine. Lab Anim. 1977;11:163–164
  16. Millichamp NJ, Collins BR. Blepharoconjunctivitis associated with Staphylococcus aureus in a rabbit. J Am Vet Med Assoc. 1986;189:1153–1154
  17. Arnbjer J. Pseudopterygium in a pygmy rabbit. Vet Med Small Anim Clin. 1979;79:737–738
  18. Fehr M. Augenanomalien beim Zwergkaninchen. Kleintierpraxis. 1984;29:129–132
  19. Ockens N. Pinguecula bilateralis hos to kaniner. Dansk Veterinaertidsskrift. 1986;69:941
  20. Matros LE, Ansari MM, Van Pent CS. Eye anomaly in a dwarf rabbit. Avian Exotic Pract. 1986;3:13–14
  21. Bauck L. Ophthalmic conditions in the pet rabbits and rodents. Compend Cont Educ Small Anim Pract. 1989;11:258–266
  22. Peiffer RL, Pohm-Thorson L, Corcoran K. Models in ophthalmology and vision research. In:  Manning PJ,  Ringler DH,  Newcomer CE editor. The Biology of the Laboratory Rabbit. San Diego: Academic Press; 1994;p. 409–433
  23. Dupont C, Carrier M, Gauvin J. Bilateral precorneal membranous occlusion in a dwarf rabbit. J Small Exotic Anim Med. 1995;3:41–44
  24. Yata S, Hara H, Kitano H, et al. Treatment of a rabbit with pseudosymblepharon. J Jap Vet Med Assoc. 1995;48:335–337
  25. Schoofs S, Hanssen P. Epicorneaal conjunctiva syndroom bij het konijn: een klinisch geval en chirurgische behandeling ervan. Vlaams Diergeneeskundig Tijdschrift. 1998;67:344–346
  26. Wagner F, Brügmann M, Heider HJ, et al. Präkorneale membranöse Okklusion bei Zwergkaninchen – ein Fallbericht mit Literaturübersicht. Prakt Tierarzt. 1998;79:404–409
  27. Roze M, Ridings B, Lagadic M. Comparative morphology of epicorneal conjunctival membranes in rabbits and human pterygium. Vet Ophthalmol. 2001;4:171–174
  28. Fisher PG. Precorneal membranous occlusion in a rabbit. Exotic DVM. 2001;3:3–4
  29. Donelly TM, Fisher PG, Lackner PA. Epicorneal membrane on the eye of a rex rabbit. Lab Anim. 2002;31:23–25
  30. Allgoewer I, Schulze H, Schäffer E: Aberrantes Konjunktivawachstum beim Kaninchen, in: Proceedings 52nd Annual Congress German Veterinary Medical Society, September 21-24, 2006, Düsseldorf, Germany, pp 116-117
  31. Janssens G, Simoens P, Muylle S. Bilateral prolapse of the deep gland of the third eyelid in a rabbit: diagnosis and treatment. Lab Anim Sci. 1999;49:105–109
  32. Morgan RV, Duddy JM, McClurg K. Prolapse of the gland of the third eyelid in dogs: a retrospective study of 89 cases (1980 to 1990). J Am Anim Hosp Assoc. 1993;29:56–60
  33. Andrew SE. Corneal diseases of rabbits. Vet Clin Exotic Anim. 2002;5:341–356
  34. Wagner F, Brügmann M, Drommer W, et al. Corneal dermoid in a dwarf rabbit (Oryctolagus cuniculi). Contemp Top Lab Anim Sci. 2000;39:39–40
  35. Styer CM, Ferrier WT, Labelle P, et al. Limbic dermoid in a New Zealand White rabbit (Oryctolagus cuniculus). Contemp Top Lab Anim Sci. 2005;44:46–48
  36. Munger RJ, Langevin N, Podval J. Spontaneous cataracts in laboratory rabbits. Vet Ophthalmol. 2002;5:177–181
  37. Weisse I, Niggeschulze A, Stotzer H. Spontane, congenitale Katarakte bei Ratte, Maus und Kaninchen. Arch Toxicol. 1974;32:199–207
  38. Gelatt KN. Congenital cataracts in a litter of rabbits. J Am Vet Med Assoc. 1975;167:598–599
  39. Bagley LH, Lavach D. Ophthalmic diseases of rabbits. Calif Vet. 1995;49:7–9
  40. Ashton N, Cook C, Clegg F. Encephalitozoonosis (nosematosis) causing bilateral cataract in a rabbit. Br J Ophthalmol. 1976;60:618–631
  41. Harcourt-Brown FM. Encephalitozoon cuniculi infection in rabbits. Sem Av Exotic Pet Med. 2004;13:86–93
  42. Wolfer J, Grahn B, Wilcock B, et al. Phacoclastic uveitis in the rabbit. Prog Vet Comp Ophthalmol. 1993;3:92–97
  43. Wolfer J, Grahn B, Taylor M, et al. Treatment of phacoclastic uveitis in the rabbit by phacoemulsification. [abstract] Trans Am Coll Vet Ophthalmol. 1995;26:12
  44. Giordano C, Weigt A, Vercelli A, et al. Immunohistochemical identification of Encephalitozoon cuniculi in phacoclastic uveitis in four rabbits. Vet Ophthalmol. 2005;8:271–275
  45. Stiles J, Didier E, Ritchie B, et al. Encephalitozoon cuniculi in the lens of a rabbit with phacoclastic uveitis: conformation and treatment. Vet Comp Ophthalmol. 1997;7:233–238
  46. Fechle LM, Sigler RL. Phacoemulsification for the management of Encephalitozoon cuniculi-induced phacoclastic uveitis in a rabbit. Vet Ophthalmol. 2002;5:211–215
  47. Hanna BL, Swain PB, Sheppard B. Recessive buphthalmos in the rabbit. Genetics. 1962;47:519–529
  48. Burrows AM, Smith TD, Atkinson CS, et al. Development of ocular hypertension in congenitally buphthalmic rabbits. Lab Anim Sci. 1995;45:443–444
  49. Van der Woerdt A. Ferrets, Rabbits and Rodents—Clinical Medicine and Surgery. In:  Quesenberry KE,  Carpenter JW editor. Ophthalmologic diseases in small pet mammals. (ed 2). Philadelphia: W.B Saunders; 2003;p. 421–428
  50. Slatter D. Fundamentals of Veterinary Ophthalmology. (ed 3). Philadelphia: WB Saunders; 2001;
  51. Brown WH, Pearce L. Melanoma (sarcoma) of the eye in a syphilitic rabbit. J Exp Med. 1926;43:807–811
  52. Virchow C. Zur Inzidenz, Differentialdiagnose und Prognose des iridoziliaren Adenoms and Adenokarzinoms bei Hund, Katze und Kaninchen. München: Inaugural Dissertation; 1996;
  53. Weissbroth SH: Neoplastic diseases, in Manning DH, Ringler CE, Newcomer CE (eds): The Biology of the Laboratory Rabbit (ed 2). Academic Press, pp 259-292
  54. Toth LA, Olson GA, Wilson E, et al. Lymphocytic leukaemia and lymphosarcoma in a rabbit. J Am Vet Med Assoc. 1990;197:627–629
  55. Wagner F, Heider HJ, Görig C. Augenkrankheiten beim Zwergkaninchen (Teil 2: Erkrankungen der Kornea, intraokuläre und retrobulbäre Erkrankungen sowie Neoplasien). Tierärztl Prax. 1998;26:345–350
  56. Wills J. Coenurosis in a pet rabbit. Vet Rec. 2001;148:188
  57. O’Reilly A, McCowan C, Hardman C, et al. Taenia serialis causing exophthalmos in a pet rabbit. Vet Ophthalmol. 2002;5:227–230
  58. Volopich S, Gruber A, Hassan J, et al. Malignant B-cell lymphoma of the Harder’s gland in a rabbit. Vet Ophthalmol. 2005;8:259–263
  59. Kostolich M, Panciera RJ. Thymoma in a domestic rabbit. Cornell Vet. 1992;82:125–129
  60. Vernau KM, Grahn BH, Clarke-Scott HA, et al. Thymoma in a geriatric rabbit with hypercalcemia and periodic exophthalmos. J Am Vet Med Assoc. 1995;206:820–822
  61. Harcourt-Brown F, Harcourt-Brown NH. Surgical removal of a mediastinal mass in a rabbit. Exotic DVM. 2002;4:59–60
  62. Wagner F, Beinecke A, Fehr M, et al. Recurrent bilateral exophthalmos associated with metastatic thymic carcinoma in a pet rabbit. J Small Anim Pract. 2005;46:393–397
  63. Drieux PH, Poisson J. Tumeur du thymus chez le lapin. Bull de l′ Academie Veterinaire de France. 1938;11:283–290
  64. Orr JW. A malignant tumor of the thymus in a rabbit. Am J Cancer. 1939;35:269–274
  65. Greene HSN, Strauss JS. Multiple tumors in the rabbit. Cancer. 1949;2:673–691
  66. Fox RR, Meier H, Crary DD, et al. Hemolytic anemia associated with thymoma in the rabbit. Genetic studies and pathological findings. Oncology. 1971;25:372–382
  67. Clippinger TL, Bennett RA, Alleman AR, et al. Removal of a thymoma via median sternotomy in a rabbit with recurrent appendicular neurofibrosarcoma. J Am Vet Med Assoc. 1998;213:1140–1143
  68. Bowenkam PKE, Roth L. What’s your diagnosis? Cranial mediastinal mass in a dwarf rabbit. Lab Anim. 1999;28:19–21
  69. Morrisey JK, McEntee M. Therapeutic options for thymoma in the rabbit. Sem Avian Exotic Pet Med. 2005;14:175–181
  70. Guzman Sanchez-Migallon D, Mayer J, Gould J, et al. Radiation therapy for the treatment of thymoma in rabbits (Oryctolagus cuniculi). J Exotic Pet Med. 2006;15:138–144
  71. Hoyt RF, Powell DA, Feldman SH: Exophthalmia in the rabbit after chronic external jugular catheter placement [abstract]. Proceedings American Association of Laboratory Animal Science Annual Meeting, 1994

PII: S1557-5063(07)00095-X

doi: 10.1053/j.jepm.2007.06.013

Journal of Exotic Pet Medicine
Volume 16, Issue 3 , Pages 158-167 , July 2007