Journal of Exotic Pet Medicine
Volume 16, Issue 1 , Pages 52-54 , January 2007

Florfenicol

  • Emily Moore, DVM

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Dr. Emily Moore, Louisiana State University, School of Veterinary Medicine, Department of Veterinary Clinical Sciences, Baton Rouge, LA 70803.

References 

  1. Plumb D. Florfenicol. In:  Plumb D editors. Veterinary Drug Handbook. ed 5. Ames, IA: Iowa State Press; 2004;p. 335–336
  2. Neu HC, Fu KP. In vitro activity of chloramphenicol and thiamphenicol analogue. Antimicrob Agents Chemother. 1980;18:311–316
  3. Yunis AA. Chloramphenicol: relation of structure to activity and toxicity. Annu Rev Pharmacol Toxicol. 1988;28:83–100
  4. Shin SJ, Kang SG, Nabin R, et al. Evaluation of the antimicrobial activity of florfenicol isolated against bacteria from a bovine and porcine respiratory disease. Vet Microbiol. 2005;106:73–77
  5. Wilson DJ, Sears PM, Gonzalez RN, et al. Efficacy of florfenicol for treatment of clinical and subclinical bovine mastitis. Am J Vet Res. 1996;57:526–528
  6. Lobell RD, Varma KJ, Johnson JC, et al. Pharmacokinetics of florfenicol following intravenous and intramuscular doses to cattle. J Vet Pharmacol Therap. 1994;17:253–258
  7. Alcorn J, Dowling P, Woodbury M, et al. Pharmacokinetics of florfenicol in North American elk (Cervus elaphus). J Vet Pharmacol Therap. 2004;27:289–292
  8. Shen J, Hu D, Wu X, et al. Bioavailability and pharmacokinetics of florfenicol in broiler chickens. J Vet Pharmacol Therap. 1998;26:337–341
  9. El-Banna HA. Pharmacokinetics of florfenicol in normal and Pasteurella-infected Muscovy ducks. Brit Poult Sci. 1998;39:492–496
  10. Abd El-Aty AM, Goudah A, Abo El-Sooud K, et al. Pharmacokinetics and bioavailability of florfenicol following intravenous, intramuscular and oral administration in rabbits. Vet Res Comm. 2004;28:515–524
  11. Lewbart GA. The latest in antimicrobials for pet fish. Exotic DVM. 2001;3:80–82
  12. Samuelson OB, Bergh O, Ervik A. Pharmacokinetics of florfenicol in cod Gadis morhua and in vitro antimicrobial activity against Vibrio anguillarum. Dis Aquat Organ. 2003;56:127–133
  13. Yanong RPE, Curtis EW. Pharmacokinetic studies of florfenicol in koi carp and three-spot gourami, Trichogaster tricopterus, after oral and intramuscular treatment. J Aqua Anim Health. 2005;17:129–137
  14. Aquaflor product information (Schering-Plough Aquaculture). Accessed December 2005. Available from. URL:http://www.spaquaculture.com
  15. McGinnis A, Gaunt P, Santucci T, et al. In vitro evaluation of the susceptibility of Edwardsiella ictaluri, etiologic agent of enteric septicemia in channel catfish, Ictalurus punctatus (Rafinesque), to florfenicol. J Vet Diag Invest. 2003;15:576–579
  16. Samuelson OB, Hjeltnes B, Glette J. Efficacy of orally administered florfenicol in the treatment of furunculosis in Atlantic salmon. J Aqua Anim Health. 1998;10:56–61
  17. Lunden T, Miettinen S, Lonnstrom LG, et al. Effect of florfenicol on the immune response of rainbow trout (Oncorhynchus mykiss). Vet Immunol Immunopathol. 1999;67:317–325
  18. Gaikowski MP, Wolf JC, Endris RG, et al. Safety of Aquaflor (florfenicol, 50% type A medicated article), administered in feed to channel catfish, Ictalurus punctatus. Toxicol Pathol. 2003;31:689–697
  19. Martinsen B, Horsberg TE, Varma KJ, et al. Single-dose pharmacokinetic study of florfenicol in Atlantic salmon (Salmo salar) in sea water at 11°C. Aquacult. 1993;112:1–11
  20. Horsberg TE, Hoff KA, Nordmo R. Pharmacokinetics of florfenicol and its metabolite florfenicol amine in Atlantic salmon. J Aqua Anim Health. 1996;8:292–301
  21. Ho SP, Hsu TY, Chen MH, et al. Antibacterial effect of chloramphenicol, thiamphenicol and florfenicol against aquatic animal bacteria. J Vet Med Sci. 2000;62:479–485
  22. Michel C, Keroualt B, Martin C. Chloramphenicol and florfenicol susceptibility of fish-pathogenic bacteria isolated in France: comparison of minimum inhibitory concentration, using recommended provisory standards for fish bacteria. J Appl Microbiol. 2003;95:1008–1015
  23. Bretzlaff KN, Neff Davis CA, Ott RS, et al. Florfenicol in non-lactating dairy cows: pharmacokinetics, binding to plasma proteins, and effects on phagocytosis by blood neutrophils. J Vet Pharmacol Therapeu. 1987;10:233–240
  24. Paape MJ, Miller RH, Ziv G. Effects of florfenicol, chloramphenicol, and thiamphenicol on phagocytosis, chemiluminescence, and morphology of bovine polymorhphonuclear neutrophil leucocytes. J Dairy Sci. 1990;7:1734–1744
  25. Stamper MA, Papich MG, Lewbart GA, et al. Pharmacokinetics of florfenicol in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections. J Zoo Wildl Med. 2003;34:3–8

PII: S1557-5063(06)00183-2

doi: 10.1053/j.jepm.2006.11.010

Journal of Exotic Pet Medicine
Volume 16, Issue 1 , Pages 52-54 , January 2007

Article Tools