Journal of Exotic Pet Medicine
Volume 15, Issue 1 , Pages 59-65 , January 2006

Wobbly Hedgehog Syndrome in African Pygmy Hedgehogs (Atelerix spp.)

  • Donnasue Graesser, Ph.D.

      Affiliations

    • Yale University School of Medicine, Departments of Pathology and Comparative Medicine, New Haven, CT 06510 USA
    • Corresponding Author InformationAddress correspondence to: Donnasue Graesser, Hedgehog Welfare Society, PO Box 242, Chaplin, CT 06235.
    • ,
  • Terry R. Spraker, DVM, Ph.D., Dipl. ACVP

      Affiliations

    • Colorado State University Veterinary Diagnostic Laboratory, Fort Collins, CO 80523 USA
    • ,
  • Priscilla Dressen, DVM

      Affiliations

    • NorthStar Veterinary Clinic, Fort Collins, CO 80525 USA
    • ,
  • Michael M. Garner, DVM, Dipl. ACVP

      Affiliations

    • Northwest ZooPath, Monroe, WA 98272 USA.
    • ,
  • James T. Raymond, DVM, MS, Dipl. ACVP

      Affiliations

    • Yale University School of Medicine, Departments of Pathology and Comparative Medicine, New Haven, CT 06510 USA
    • Colorado State University Veterinary Diagnostic Laboratory, Fort Collins, CO 80523 USA
    • NorthStar Veterinary Clinic, Fort Collins, CO 80525 USA
    • Northwest ZooPath, Monroe, WA 98272 USA.
    • ,
  • Gordon Terwilliger, BS

      Affiliations

    • Yale University School of Medicine, Departments of Pathology and Comparative Medicine, New Haven, CT 06510 USA
    • Colorado State University Veterinary Diagnostic Laboratory, Fort Collins, CO 80523 USA
    • NorthStar Veterinary Clinic, Fort Collins, CO 80525 USA
    • Northwest ZooPath, Monroe, WA 98272 USA.
    • ,
  • Jung Kim, MD

      Affiliations

    • Yale University School of Medicine, Departments of Pathology and Comparative Medicine, New Haven, CT 06510 USA
    • Colorado State University Veterinary Diagnostic Laboratory, Fort Collins, CO 80523 USA
    • NorthStar Veterinary Clinic, Fort Collins, CO 80525 USA
    • Northwest ZooPath, Monroe, WA 98272 USA.
    • ,
  • Joseph A. Madri, MD, Ph.D.

      Affiliations

    • Yale University School of Medicine, Departments of Pathology and Comparative Medicine, New Haven, CT 06510 USA
    • Colorado State University Veterinary Diagnostic Laboratory, Fort Collins, CO 80523 USA
    • NorthStar Veterinary Clinic, Fort Collins, CO 80525 USA
    • Northwest ZooPath, Monroe, WA 98272 USA.

References 

  1. Lawn RM , Boonmark NW , Schwartz K , et al.   The recurring evolution of lipoprotein(a) (insights from cloning of hedgehog apolipoprotein(a)) . J Biol Chem . 1995;270:24004–24009
  2. Larsen RS , Carpenter JW . Husbandry and medical management of African hedgehogs . Vet Med . 1999;94:877–890
  3. Graesser D , Dressen P , Spraker TR , et al.   Wobbly Hedgehog Syndrome (possibly a progressive lower motor neuronopathy) . Proc Annu Conf Am Ass Vet Lab Diagn Hershey, PA . 2001;44:82
  4. Ivey E , Carpenter JW . African Hedgehogs . In:  Quesenberry KE ,  Carpenter JW editor. Ferrets, Rabbits, and Rodents (Clinical Medicine and Surgery) . (ed 2).. Philadelphia, PA: WB Saunders; 2003;p. 349
  5. Graesser D , Spraker TR , Gavier-Widen D . Wobbly Hedgehog Syndrome in African pygmy and European hedgehogs . Proc Eur Hedgehog Res Group Münster, Germany . 2004;6:5
  6. Palmer AC , Blakemore WF , Franklin RJ , et al.   Paralysis in hedgehogs (Erinaceus europaeus) associated with demyelination . Vet Rec . 1998;143:550–552
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  8. Raymond JT , White MR . Necropsy and histopathologic findings in 14 African hedgehogs (Atelerix albiventris) (a retrospective study) . J Zoo Wild Med . 1999;30:273–277
  9. Lassman H . Classification of demyelinating diseases at the interface between etiology and pathogenesis . Curr Opin Neurol . 2001;14:253–258
  10. Vandevelde M , Zurbriggen A . Demyelination in canine distemper virus infection (a review) . Act Neuropathol . 2005;109:56–68
  11. Greenlee JE . Progressive multifocal leukoencephalopathy–progress made and lessons relearned . N Engl J Med . 1998;338:1378–1380
  12. Hohlfeld R , Wekerle H . Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy (from pipe dreams to (therapeutic) pipelines) . Proc Natl Acad Sci . 2004;101(suppl 2):14599–14606
  13. Weiner HL . Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease . Arch Neurol . 2004;61:1613–1615
  14. Musana AK , Yale SH . Central pontine myelinolysis (case series and review) . Wisc Med J . 2005;104:56–60
  15. Churcher RK , Watson AD , Eaton A . Suspected myelinolysis following rapid correction of hyponatremia in a dog . J Am Anim Hosp Assoc . 1999;35:493–497
  16. O’Brien DP , Kroll RA , Johnson GC , et al.   Myelinolysis after correction of hyponatremia in two dogs . J Vet Intern Med . 1994;8:40–48
  17. Baslow MH . Canavan’s spongiform leukodystrophy (a clinical anatomy of a genetic metabolic CNS disease) . J Mol Neurosci . 2000;15:61–69
  18. Koeppen AH , Robitaille Y . Pelizaeus-Merzbacher disease . J Neuropathol Exp Neurol . 2002;61:747–759
  19. Cuddon PA , Lipsitz D , Duncan ID . Myelin mosaicism and brain plasticity in heterozygous females of a canine X-linked trait . Ann Neurol . 1998;44:771–779
  20. Nadon NL , Duncan ID , Hudson LD . A point mutation in the proteolipid protein gene of the ‘shaking pup’ interrupts oligodendrocyte development . Development . 1990;110:529–537
  21. Duncan ID . The PLP mutants from mouse to man . J Neurol Sci . 2005;228:204–205

PII: S1557-5063(05)00106-0

doi: 10.1053/j.jepm.2005.11.010

Journal of Exotic Pet Medicine
Volume 15, Issue 1 , Pages 59-65 , January 2006

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